Predicting the Effects of Single Mutations on Protein Stability
Algorithm15

An example of using the calculation of a monomeric protein using the example of P53 mutations. Calculations made it possible to separate neutral mutations from oncological mutations of the P53 protein.
bio calculations
calculation results
oncological mutations
Calculation results for negative and Positive set of P53 muttaions

Start calculate Effects of Single Mutations
on Protein Stability right now!

You can either regularly use the server services and

stay in touch with specialists, or cancel them at any time.


  1. Collection of materials,
  2. Technical assignment,
  3. Calculations up to N variants,
  4. Obtaining data
  5. Data processing,
  6. Sorting,
  7. Plotting graphs,
  8. Dependencies,
  9. Explanatory note for each calculation
  10. Starting with 50 mutations, machine learning methods will be applied.

If you need 200 mutations or more, then the price increases proportionally with a decreasing coefficient, i.e. the calculation of one mutation when ordering 200 mutations will be cheaper than the cost of 1 mutation when ordering 10 mutations.

Preliminary set
Small amount up to 10
$50
Explanatory notes for each calculation
Second Set
Average amount up to 20
$70
Calculations up to 20 variants.
Explanatory notes for each calculation
Second Set
Average amount up to 50
$130
Calculations up to 50 variants.
Explanatory notes for each calculation
Special set
Larch amount up to 100
$249
Calculations up to 100 variants.
Explanatory notes for each calculation

Input data

  • Load PDB file of one protein structures,
  • select amount of mutaions,
  • Serial number of a.a. in PDB file,
  • new indicates of a.a.
The results will be automatically sent to your e-mail.
InPut PDB of protein srtucture

Our service provides a fast and easy way to perform complex bioinformatics calculations. With our user-friendly interface, you can quickly submit your data and get results within minutes. We also offer many advanced features to help you get the most out of your calculations.

Example of PDB file structure:
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