CDK9-Cyclin T

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been
implicated as prominent drivers of tumorigenesis

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Adenosine Triphosphate (ATP) Binding Motif forms a cleft between the N- and C-terminal lobes and is highly conserved among CDKs

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The major cyclin partner of CDK9, cyclin T (‘T’ named after the first letter of HIV TAT), has a close similarity to cyclin C and cyclin H. HIV TAT interacts only with cyclin T1 in complex with CDK9 to mediate HIV transcription

CDK9-cyclin T2a interacts directly with
myoblast determination protein 1 (MyoD)

CDK9-cyclin T1 activates muscle
differentiation programs by stimulating the transcription
program of myocyte enhancer factor 2 [MEF2]

CDK9-cyclin T1 is also required for the differentiation of monocytes, lymphocytes, adipocytes, and neurons.