Symbol:KSR2
Name:kinase suppressor of ras 2
Synonyms: FLJ25965
NCBI Gene:283455
UniProtKB Swiss-Prot: Q6VAB6
Adenoma and adenomacarcinomas
Gliomas, Epithelial Neoplasms, NOS
Adenomas and Adenocarcinomas
Cystic, Mucinous and Serous Neoplasms
Epithelial Neoplasms, NOS
Ductal and lobular neoplasms
Adenomas and Adenocarcinomas
Ductal and Lobular Neoplasms
Gliomas
Mutations of KSR2 have no effect on cellular localisation of KSR2, but many disrupt MAPK/ERK signalling.
Most variants were found in heterozygous form, although one severely obese individual was homozygous for two KSR2 variants (R253W and D323E).
Focused on variants that disrupt (frame-shift/nonsense) or are likely to disrupt (missense mutations in or very close to) the highly conserved kinase domain of KSR2.