What do we have for obtaining information about the direction of a biochemical reaction?
Analysis of the biochemical complex N1
We investigate how the physical parameters characterizing system N1 (wtBRAF) change when the system transitions to state N6 and N3 (mutBRAF)
Each protein complex has its own physical parameters that determine the interaction:
The analysis of changes in these values makes it possible to detect the formation and decay of biological complexes, as well as to rank biological complexes according to their degree of affinity.
Determining the pathways of biochemical processes
- The fraction of non-dissociated molecules after the reaction and concentration protein-ligand complex
- Entropy Change . The case of a one-dimensional normal distribution
4.Constant dissociation
5. Enthalpy change
6. The thermal dissociation
7. Potential energy of electrostatic interaction between all amino acid residues taken in pairs
Additional calculated parameters:
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