Preliminary results using a bioinformatics server to obtain thermodynamic parameters of the interaction of proteins with small chemical molecules
Step-by-step use of the server for calculating various biological complexes: monomer, dimer, tetramer, monomer+inhibitor, tetramer+2 inhibitors, etc. Subsequent analysis of the obtained thermodynamic parameters will allow to build biochemical processes occurring in normal and malignant cells
Results: The calculation of the physical quantities of interaction characterizing the formation of each complex reveals the direction of the passage of biochemical reactions depending on the affinity and concentration of active elements, thus the platform will help determine stable and transient biological formations with the participation of the studied drugs.
Link: http://biomarker.co.il/scheme2
Get a set of calculated physical quantities for each biological complex in the biochemical cascade and build a diagram and order of interaction of biological molecules in the cell (and beyond) for biotech companies
Link: http://biomarker.co.il/scheme3
We will be very grateful for any possible assistance to the developers!
Here you can ask a question about your personal research specifics; perhaps you have not found the section that is suitable for you, ask a question or attach a file. Electronic box for feedback: server@binomlabs.com
Responsible editor-in-chief in the field of mathematical physics and machine learning:
Doctor of Habilitation in theoretical and math.phisics. Professor at the department of theoretical physics and the department of higher mathematics, Kirill Mazel's ( Ashkenazi) 3321108, Haifa, Israel
