Use AI to predict biochemical data
Product Line
The correlations were performed on real solutions in a biochemical laboratory.
Selection of flexible antibody chains to antigen, determination of affinity, change in entropy, dissociation energy for each modification of the antibody.
-modification of antibody flexible chains,
-stepwise testing of each antibody to antigen,
-determination of key amino acid residues,
-range of changes in affinity.
-modification of antibody flexible chains,
-stepwise testing of each antibody to antigen,
-determination of key amino acid residues,
-range of changes in affinity.
Preclinical research
Comparison of producer prices and AI calculations
Molecular Profiling of Tumors:
The Future of Personalized Medicine.
Analysis of the biochemical reaction scheme taking into account the characteristics of each patient's disease, since the concept of "oncological disease" is a complex disease, the obtained results will then be sorted into certain groups according to the characteristics obtained.
The Future of Personalized Medicine.
Analysis of the biochemical reaction scheme taking into account the characteristics of each patient's disease, since the concept of "oncological disease" is a complex disease, the obtained results will then be sorted into certain groups according to the characteristics obtained.
Antibody-Antigen
Preclinical phase research
Preclinical development of new medicines
Calculation of the influence of ions and ATP molecules on the physical properties of proteins, monomers, dimers, tetramers.
Study of small inhibitors, calculation of atomic charges, comparison of the obtained results, construction of comparative graphs so that the experimenter could see a preliminary possible experimental results
Study of small inhibitors, calculation of atomic charges, comparison of the obtained results, construction of comparative graphs so that the experimenter could see a preliminary possible experimental results
Protein+Inhibitor+Atom
The influence of small inhibitors on protein interactions
Price list /Main categories of molecular complexes with small inhibitors or atoms, and a list of prices for calculating each molecular complex.
Features
Set one
Set two
Set Three
Set Four
[Monomer+Inhibitor] or Atom
up to 10 mutations
up to 40 mutations
up to 150 mutations
up to 250 mutations
[3-4weeks]
[3-4weeks]
up to TWO inhibitors
[Dimer+Inhib.1+Inhib.2] or Atoms
up to 30 mutations
up to 100 mutations
up to 150 mutations
[3-5 weeks]
[3-5 weeks]
up to 4 inhibitors
[Tetramer+Several Inh-s]
[Trimer+Several Inhib-s]
[Trimer+Several Inhib-s]
up to 10 mutations
up to 50 mutations
[6-8 weeks]
[6-8 weeks]
[pentamer+Several Inh-s]
[any protein complex +Inh.]
[any protein complex +Inh.]
up to 10 mutations
Linear models for finding correlations
Cost AI calculations for linear sequences:
The influence of solvent characteristics and experimental conditions on the nature of biochemical reactions.
If you need to calculate the aggregation of amyloid proteins/ peptides under various experimental conditions, you can use our software or perform the calculation online on the server and get clear and understandable preliminary results taking into account various experimental conditions.
Urea Denaturation
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1. Application of optimization problems
allows you to reconstruct the RNA structure.
2. The server produces a set of data
indicating the stability of each section of RNA.
allows you to reconstruct the RNA structure.
2. The server produces a set of data
indicating the stability of each section of RNA.
Urea Denaturation
Correlation analysis between experimental and calculated data for salt solutions revealed an acceleration in achieving agreement between experimental and calculated data.
Therefore, it is advisable to carry out the calculation at low concentrations of salt in the solution 0.1mM-10mM
Therefore, it is advisable to carry out the calculation at low concentrations of salt in the solution 0.1mM-10mM
The maximum correlation dependence between the calculated and experimental values was found between lg(cond(W)) and [Urea]50 in solution.
Starting with C[Urea] >=2.8M and more.
The correlation dependence between the values reached 90%
Starting with C[Urea] >=2.8M and more.
The correlation dependence between the values reached 90%
Linear models for finding correlations
Examples of calculations of molecular biological structures using a spatial 3D model, which is provided by the customer, or we assemble it ourselves.
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Alaning scaning
Alanine scanning of consecutive amino acid residues in monomer, dimer, trimer, tetramer, list of calculated physical parameters.
Order calculation of 100 mutations for a monomeric protein or for a dimer, taking into account known 3D structures.
You can order not only alanine scanning, but also a study of any missense mutations. -
Mutagenesis, missense mutations
Analysis of the influence of point mutations on the affinity of protein molecules in dimers, tetramers, any other molecular complexes, heat maps, analysis of the influence of salt solutions, temperature conditions.
Step-by-step analysis of the influence of polypeptide chain modification on all structural levels of molecular organization -
The influence of small inhibitors on protein interactions
Calculation of the influence of ions and ATP molecules on the physical properties of proteins, monomers, dimers, tetramers.
Study of small inhibitors, calculation of atomic charges, comparison of the obtained results, construction of comparative graphs so that the experimenter could see a preliminary possible experimental results -
Selection of oncogenic from neutral mutations
You will be provided with a list of physical characteristics for each group of mutations, such as order, stability, dissociation energy, etc., graphs of the calculated values obtained, excel tables -
Assemble the contacting dimer, trimer, tetramers
You don't have a 3D structure of the compound you're interested in? We'll collect it for you and do the research you need. -
Calculation of amyloid peptides
Calculate the properties of interaction of Beta structure and amyloid peptides, which have a tendency to aggregate and increase toxicity. Obtain a direct correlation with the experiment and a descriptive and explanatory part of the obtained calculated data. -
Protein+Inhibitor
Get a list of physical parameters obtained by calculating the influence of small inhibitors and atoms on the properties of the molecule structure, graphs, excel files with data, description of the results obtained -
Saline Solutions:
Taking into account the influence of the concentration of salt in an aqueous solution on the properties of protein interactions, the calculation is based on the Gouy-Chapman theory - screening of charged amino acid residues by salt counterions at low salt concentrations in an aqueous solution. -
Urea protein denaturation
Obtain a direct correlation for Unfolding proteins under the influence of urea concentration and calculated data. At a Urea concentration of more than 2.6M, the correlation with experimental data reaches 89%
Molecular 3D structure calculations
Start calculate Effects of Single Mutations on Protein Stability (Aggregation) right now!
We offer to study an individual peptide only for 2.49 Euro, using AI and machine learning methods. Obtain a complete set of physical interaction parameters rpteoins
We offer to study an individual peptide only for 2.49 Euro, using AI and machine learning methods. Obtain a complete set of physical interaction parameters rpteoins
Load a simple letter sequence of two protein sequences, while trying to ensure that the length of the proteins is a multiple of the length of the specified shift frame. The results will be automatically sent to your e-mail.
Monomers-Dimers Deep learning
Trimers-Tetramers Deep learning
We present the developed algorithm for a step-by-step transparent and understandable search for interaction areas, each of which will be characterized by numerical physical quantities. Use the linear docking method developed by us, which allows us to determine the most stable binding regions according to the amino acid sequence.
Individual study of the effect of mutations on complex formation, taking into account complex structures: dimers, tetramers, pentamers, taking into account the influence of additional structures: small inhibitors, allosteric inhibition, binding to DNA and RNA
Comparisone of prices
Type of Calculations
Individual orders for research
Individual study of the effect of mutations on complex formation, taking into account complex structures: dimers, tetramers, pentamers, taking into account the influence of additional structures: small inhibitors, allosteric inhibition, binding to DNA and RNA
Selection of oncogenic from neutral mutations
Oncogenic mutations
Select mutations
Type of Monomers Calculations
Type of Trimer Calculations
Number of Substitutions:
up 100 Alanines
Perform alanine scanning of a large size monomeric protein with sequential replacement of amino acid residues in the polypeptide chain with alanine and obtain a set of changes in physical characteristics compared to the wild-type monomer.
Alaning scaning/Mutagenesis of large size monomeric/dimer protein
The length of the protein polypeptide chain is up to 1300 a.a.
Price:
Number of Substitutions
in one protein:
in one protein:
up 30 Mutations
up 50 Mutations
up 100 Mutations
Perform alanine/Missence mutations scanning for dimer with sequential replacement of amino acid residues in one polypeptide chain and obtain a set of changes in physical characteristics compared to the wild-type monomer.
Perform an alanine scan of the polypeptide chain with known 3D structures
Trimers/Tetramers
Trimers/Tetramers
Price:
Duration:
about Month
about 6 -8 weeks
about 8-10 weeks
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Quantum problems, search for correlation laws, statistics, machine learning methods
Our team is engaged in fundamental research, so we will be glad to cooperate and your question via the feedback form!
Search for correlation laws
Shielding effect
Searching for Correlation
